6/15/2023 0 Comments Cpap in boundary waters![]() We found, among others, that some aerobic and anaerobic glycolytic enzymes and Krebs cycle enzymes were downregulated, suggesting that apnea may be a result of paucity of oxygen and production of ATP and reducing equivalents. We recently performed a pilot study using onedimensional polyacrylamide gel electrophoresis (1D PAGE) and nanoliquid chromatography-tandem mass spectrometry (NanoLC-MS/MS) to investigate the protein dysregulations in rat atria which was induced with OSA using the rat model we developed. Rats were divided into severe and moderate apnea groups, receiving 23 seconds (severe) or 13 seconds (moderate) apneas per minute, 60 apneas per minute for 8 hours a day over 2 weeks. We have implemented a rat model of OSA involving the surgical implantation of a tracheal obstructive device. OSA has been associated with electrical and structural abnormalities of the atria, although the molecular mechanisms are not well understood. Obstructive sleep apnea (OSA) affects an estimated 20% of adults worldwide with up to 80% of patients remaining undiagnosed.
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